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抽象摘要

使用豚鼠作為模型宿主，我們表明流感病毒的氣溶膠傳播取決於環境相對濕度和溫度。

Twenty experiments performed at relative humidities from 20% to 80% and 5°C, 20°C, or 30°C indicated that both cold and dry conditions favor transmission.

在每個實驗中，八隻動物被儲存在Caron 6030環境室中。將每個豚鼠放在自己的籠子裏，每個架子都定位在每個架子上。將幼稚動物置於受感染的動物身後，使得氣流方向朝向幼稚動物。

The cages used were open to airflow through the top and one side, both of which were covered by wire mesh. Although infected and exposed guinea pigs were placed in pairs, air flowed freely between shelves, allowing transmission to occur from any infected to any naïve animal.

Results summary

The results of transmission experiments performed at 20 °C and five different RHs (20%, 35%, 50%, 65%, and 80%) indicated that the efficiency of aerosol spread of influenza virus varied with RH.

Transmission was highly efficient (occurred to three or four of four exposed guinea pigs) at low RH values of 20% or 35%. At an intermediate RH of 50%, however, only one of four naïve animals contracted infection. Three of four exposed guinea pigs were infected at 65%RH, while no transmission was observed at a high RH of 80%.

在20°C時，低RH的傳播效率最高，當氣溶膠中的流感病毒群體相對穩定時，呼出的呼吸液滴的幹燥產生液滴核。當病毒顆粒相對不穩定時，中間rh在中間r r r降低，但在更高的濕度下與流感病毒穩定性平行改善。在高Rh處，呼出顆粒的蒸發是有限的，呼吸液滴從空氣中沉降，並且透射率被堵塞。在5℃下，透射比在20℃下更有效，但在更高的濕度下減少到50％的速率。

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